- Student Government Association
- African American Association
- Agriculture Club
- American Dental Hygienists
- Art Club
- Basketball Club
- College Democrats
- College Republicans
- Communications Club
- Dental Students Association
- DeSoto Campus Ambassadors
- Hardee Campus Ambassadors
- Institute for Healthcare Improvement (IHI)
- Jac Pac
- Latin Student Organization
- Phi Beta Lambda
- Phi Theta Kappa
- Radiography Club
- Rotaract
- Soccer Club
- Student Nurses Association
- Student Practical Nurses
- Veterans Club of South Florida State College (VCSFSC)
- Volleyball Club
American Dental Hygienist
Dental hygiene students are the only students permitted to be members of this club. Club members participate in various community service projects. Members provide oral health education, oral cancer screenings and dental hygiene treatment to the public. Members even have the chance to attend Special Olympics where they volunteer completing dental screenings.
