- Student Government Association
- African American Association
- Agriculture Club
- American Dental Hygienists
- Art Club
- Basketball Club
- College Democrats
- College Republicans
- Communications Club
- Dental Students Association
- DeSoto Campus Ambassadors
- Hardee Campus Ambassadors
- Institute for Healthcare Improvement (IHI)
- Jac Pac
- Latin Student Organization
- Phi Beta Lambda
- Phi Theta Kappa
- Radiography Club
- Rotaract
- Soccer Club
- Student Nurses Association
- Student Practical Nurses
- Veterans Club of South Florida State College (VCSFSC)
- Volleyball Club
Art Club
The SFSC Art Club strives to provide enlightenment through the arts and music for students and the campus community. Its goals are to provide education and entertainment through art, music, and culture, promote participation in artistic educational activities, promote student involvement in service activities, and promote creative and leadership qualities among students by providing a “right-brain” inspiring environment.