- Student Government Association
- African American Association
- Agriculture Club
- American Dental Hygienists
- Art Club
- Basketball Club
- College Democrats
- College Republicans
- Communications Club
- Dental Students Association
- DeSoto Campus Ambassadors
- Hardee Campus Ambassadors
- Institute for Healthcare Improvement (IHI)
- Jac Pac
- Latin Student Organization
- Phi Beta Lambda
- Phi Theta Kappa
- Radiography Club
- Rotaract
- Soccer Club
- Student Nurses Association
- Student Practical Nurses
- Veterans Club of South Florida State College (VCSFSC)
- Volleyball Club
College Republicans
College Republicans is a political interest club that is active in the politics of the area, the state, and the nation.
