- Student Government Association
- African American Association
- Agriculture Club
- American Dental Hygienists
- Art Club
- Basketball Club
- College Democrats
- College Republicans
- Communications Club
- Dental Students Association
- DeSoto Campus Ambassadors
- Hardee Campus Ambassadors
- Institute for Healthcare Improvement (IHI)
- Jac Pac
- Latin Student Organization
- Phi Beta Lambda
- Phi Theta Kappa
- Radiography Club
- Rotaract
- Soccer Club
- Student Nurses Association
- Student Practical Nurses
- Veterans Club of South Florida State College (VCSFSC)
- Volleyball Club
DeSoto Campus Ambassadors
The DeSoto Campus Ambassadors serves as the represented influence and voice of the students attending the SFSC DeSoto Campus with direct liaison through SGA. In addition to promoting educational and student social activities, this organization encourages good citizenship in the community through approved service activities.
