- Student Government Association
- African American Association
- Agriculture Club
- American Dental Hygienists
- Art Club
- Basketball Club
- College Democrats
- College Republicans
- Communications Club
- Dental Students Association
- DeSoto Campus Ambassadors
- Hardee Campus Ambassadors
- Institute for Healthcare Improvement (IHI)
- Jac Pac
- Latin Student Organization
- Phi Beta Lambda
- Phi Theta Kappa
- Radiography Club
- Rotaract
- Soccer Club
- Student Nurses Association
- Student Practical Nurses
- Veterans Club of South Florida State College (VCSFSC)
- Volleyball Club
Veterans Club of South Florida State College (VCSFSC)
This club consists of students who are active duty, reservists, retired, veterans, spouses, and/or dependents of all military branches of service. VCSFSC meets on a regular basis to enhance their college experience through an exchange of ideas, engagement in military-related service projects at all SFSC campuses and throughout the community, assist with the dissemination of valuable information to veterans, building upon their past and present military experience to further their own educational pursuits, and enrich the overall population at SFSC.